House created a sophisticated array of lasers which would shoot down any missiles approaching Las Vegas. House was convinced that civilization had under 15 years left, and in 2077, he was proven correct. House predicted the likelihood of a devastating nuclear war long before the bombs dropped. RobCo was hugely successful, producing iconic inventions from the Pip-Boy to Liberty Prime. A mathematical genius, House began running computer programs to predict some major events in the markets and political landscape. Born in 2020, House attended the Commonwealth Institute of Technology, founding RobCo Industries while he was still a young man. It is between World War 2 and the Great War that New Vegas' Robert House, AKA Mr. Some humans were able to shelter themselves in Vaults, while others were transformed into Fallout's Ghouls by the radiation.
Over the course of just two hours, much of human civilization was destroyed.
Eventually, the timeline divergence leads to the Great War of 2077, which is the main inciting incident of the Fallout universe. The Fallout timeline officially diverges from the real timeline roughly around World War 2, though there are some events like the alien abduction of the historical characters seen in Fallout 3's Mothership Zeta DLC which take place beforehand.